Topic 110

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136 items. Top items listed below.

Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain. 110 27 10 3

Interleukin-35 pretreatment attenuates lipopolysaccharide-induced heart injury by inhibition of inflammation, apoptosis and fibrosis 110 10 3

Macrophage-derived miR-21 drives overwhelming glycolytic and inflammatory response during sepsis via repression of the PGE2/IL-10 axis. 110 27 10 3

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages 110 27 10 3

Interleukin-19 alleviates experimental autoimmune encephalomyelitis by attenuating antigen-presenting cell activation 110 27 10 3

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner 110 32 27 10 3

GLP-1R agonist NLY01 reduces retinal inflammation, astrocyte reactivity, and retinal ganglion cell death secondary to ocular hypertension. 110 72 10 3

Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages 110 27 10 3

Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis. 110 27 10 3

STAT3 Serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression 110 27 10 3

Mutant glucocorticoid receptor binding elements on Interleukin-6 promoter regulate dexamethasone effects 110 27 10 3

Neonatal immune challenge induces female-specific changes in social behavior and somatostatin cell number, independent of microglial inflammatory signaling 110 56 27 11 10 2

MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge: implications for Rett Syndrome. 110 27 10 3

Luteolin transforms the BMDM polarity to regulate the expression of inflammatory factors 110 27 10 3

Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice 110 27 10 3

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice 110 11 10 3

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-gamma pathway in primary microglia 110 10 3

Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration 110 32 27 10 3

Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice 110 27 10 3

AIM2 Inflammasome Mediates Hallmark Neuropathological Alterations and Cognitive Impairment in a Mouse Model of Vascular Dementia 110 10 3

Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response 110 27 10 3

Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice 110 10 3

Amyloid beta acts synergistically as a pro-inflammatory cytokine 32 27 3

LAG3 is a Central Regulator of NK Cell Cytokine Production 27 10 3

Role of necroptosis in chronic hepatic inflammation and liver disease in Cu/Zn superoxide dismutase deficient mice 110 10 3

Neuraminidase activity mediates IL-6 production through TLR4 and p38/ERK MAPK signaling in MRL/lpr mesangial cells 110 27 10 3

Characterization of Stanniocalcin-1 Expression in Macrophage Differentiation 110 27 10 3

Transcriptional regulation of ACSL1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation 150 110 49 3

NAD+ prevents septic shock by non-canonical inflammasome blockade and IL-10 110 27 10 3

Fusobacterium nucleatum host cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration 110 108 14 10 3

Mast Cells Contribute to the Immunomodulatory Effect of the Biomaterial Microenvironment in a Gender Specific Manner 110 27 10 3

IL-23 production is regulated via an MSK1/2 - CREB dependent signaling pathway downstream of Toll like receptors. 110 27 10 3

Identification of Hyal2-expressing tumor-associated myeloid cells in cancer: implications for cancer-related inflammation through enhanced hyaluronan degradation 110 27 10 3

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140 110 27 3

Serum cytokine levels are modulated by specific frequencies, amplitudes, and pulse widths of vagus nerve stimulation 110 10

Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs 36 1

Neural inflammation alters synaptic plasticity probed by 10 Hz repetitive magnetic stimulation 110 77 11 10 2

Monocytes mediate Salmonella Typhimurium-induced tumour growth inhibition 110 27 10 3

Extracellular DJ-1 induces sterile inflammation in the ischemic brain 150 110 27 10 3

TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration 150 110 27 3

Interleukin-11 is a Marker for Both Cancer- and Inflammation-Associated Fibroblasts that Contribute to Colorectal Cancer Progression 110 108 14 10 3

Priming of MSCs with inflammation-relevant signals affects extracellular vesicle biogenesis, surface markers, and modulation of T cell subsets 110 10 3

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection 27 10 3

Cutaneous Wounds in Mice Lacking Tumor Necrosis Factor-stimulated Gene-6 Exhibit Delayed Closure and an Abnormal Inflammatory Response 174 110 27 10 3

Activation of the pro-resolving receptors Fpr2/3 attenuate lipopolysaccharide-induced inflammatory microglial activation 110 7 3

IL-6 signalling protects zebrafish larvae during Staphylococcus epidermidis infection in a novel bath immersion model 110 27 10 3

Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1+ macrophages regulates the intestinal cytokine milieu 110 27 10 3

Immunosuppressive effect of the Fusarium secondary metabolite butenolide in human colon epithelial cells. 110 64 10 3

The antidepressant effects of asperosaponin VI are mediated by the suppression of microglial activation and reduction of TLR4/NF-kB induced IDO expression 110 10 3

TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells 32 10 3

Maternal separation stress experienced by parents affects ovarian function in first generation of mice 110 10 3

Anti-inflammatory role of GM1 and modulatory effects of gangliosides on microglia functions 110 10 3

Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction 110 10 3

Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro 110 10

Time-dependent dual effect of NLRP3 inflammasome in brain ischemia 110 10 3

An integrin receptor complex mediates filamentous Tau-induced activation of primary astrocytes 110 102 3

Visualization and Modeling of Inhibition of IL-1β and TNFα mRNA Transcription at the Single-Cell Level 110 27 3

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB 73 27 1

Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis 110 10 3

Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells 27 10 3

LPS induces GFAT2 expression to promote O-GlcNAcylation and attenuate inflammation in macrophages 150 110 27 3

Type I Interferon regulates cytokine-delayed neutrophil apoptosis, reactive oxygen species production and chemokine expression via activation of p38 MAPK 110 7 3

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice 110 27 10 3

A Novel Role for the Nuclear Receptor, NR4A1, in Klebsiella pneumoniae Lung Infection 27 10 3

RNA-binding protein RBM3 negatively regulates innate lymphoid cells (ILCs) and lung inflammation 27 3

Engineering of extracellular vesicles for display of protein biotherapeutics 110 85 10 3

Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation 39 27 10 3

Low doses of radiation increase the immunosuppressive profile of lung macrophages during viral infection and pneumonia 73 27 10 1

Neuron-intrinsic NF-κB Signaling Mediates Reovirus Virulence 110 27 10 3

Leukotriene B4 licenses inflammasome activation to enhance skin host defense 150 110 27 10 3

Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain 110 10 3

Heparin as an Anti-Inflammatory Agent 110 10 3 1

Neuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina 72 27 3

Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis 110 14 10 3

Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment 110 10 3

Modulation of the mTOR pathway plays a central role in dendritic cell functions after Echinococcus granulosus antigen recognition. 27 10 3

A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip 73 1

Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells 110 10 3

Single-cell RNA sequencing of Tocilizumab-treated peripheral blood mononuclear cells as an in vitro model of inflammation 110 27 10 3

Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence 110 108 10 3

A Novel CD206 Targeting Peptide Inhibits Bleomycin Induced Pulmonary Fibrosis in Mice 110 10 3 1

T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2 88 27 10 3

SOCS1/SOCS3 Immune Axis Modulates Synthetic Perturbations in IL6 Biological Circuit for Dynamical Cellular Response 110 27 3

Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy 110 27 10 3

Loss of the extracellular matrix molecule tenascin-C leads to absence of reactive gliosis and promotes anti-inflammatory cytokine expression in an autoimmune glaucoma mouse model 110 72 10 3

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures 73 1

Clusterin secretion is attenuated by pro-inflammatory cytokines in culture models of cartilage degradation 110 10 3

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α 110 27 10 3

Microglia Stimulate Zebrafish Brain Repair Via a Specific Inflammatory Cascade 110 3

New insights into TNFα/PTP1B and PPARγ pathway through RNF213- a link between inflammation, obesity, insulin resistance and Moyamoya disease 110 27 10 3

Urokinase receptor associates with TLR4 interactome to promote LPS response 150 110 27 3

Metabolic Immunomodulation, Transcriptional Regulation, and Signal Protein Expression Define the Metabotype and Effector Functions of Five Polarized Macrophage Phenotypes 27 10 3

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis 174 27 10 3

Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer 14 10 3

Quantitative assessment of morphology and sub-cellular changes in macrophages and trophoblasts during inflammation 110 10

Role for both myeloid and plasmacytoid DC in driving primary T helper cell response to Burkholderia pseudomallei in healthy individuals. 27 10 3

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes 27 10 3

Immunosuppressive role of PGE2 during human tuberculosis 27 10 3

Identification of lactate as a potential inhibitory factor within epithelial cell supernatant and its effects on type 2 T cell populations 27 10 3

Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute Clostridioides difficile infection 27 10 3