Topic 153

biodistribution delivery therapeutic antibody vivo bioengineering anti nanoparticles mouse therapy uptake mice blood nanoparticle intravenous efficacy targeting liver safety treatment administration drug tumor dose antibodies murine inflammation effective targeted organs significant acute fusion monoclonal cause toxicity cancer clinical injection barrier bbb therapies spliced doses expressing f8 promising engineered preclinical against fibronectin mab vitro immunomodulatory improved cells eda transgenic humanized treating accumulation target chemotherapeutic models serum after kidney necrosis agent burden transcytosis route antigen administered alternatively conjugated ex green vectors lung development vascular morbidity invasive selectively myocardial cell spleen patients agents nanomolar bearing potential disease recombinant injury tumors established treated body

55 items. Top items listed below.

Antibody-mediated delivery of LIGHT to the tumor boosts Natural Killer cells and delays tumor progression 153 10 3

Antibody-based delivery of Interleukin-9 to neovascular structures: therapeutic evaluation in cancer and arthritis 153 10 3

Edaravone-Loaded Mesoscale Nanoparticles Treat Cisplatin-Induced Acute Kidney Injury 153 126 10 3

Blood-brain barrier transport using a high-affinity, brain-selective VNAR (Variable Domain of New Antigen Receptor) antibody targeting transferrin receptor 1 153 10

Tracking Adoptive T Cell Therapy Using Magnetic Particle Imaging 153 126 10 3

Engineering murine GITRL for antibody-mediated delivery to tumor-associated blood vessels 153 126 10 3

Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX 153 126 14 10 3

An engineered 4-1BBL fusion protein with ''activity-on-demand'' 153 7 3

Chemotherapeutic Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Fertility and Anticancer Activity 153 126 10

Broad gene expression throughout the mouse and marmoset brain after intravenous delivery of engineered AAV capsids 153 33 10

Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers 153 10 3

Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model 153 64 10

Nrf2 activator-encapsulating polymeric nanoparticles and LDL-like nanoparticles target atherosclerotic plaque 153 10

Myocardial damage induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. 153 10

Systemic Brain Tumor Delivery of Synthetic Protein Nanoparticles for Glioblastoma Therapy 153 126 14 10 3

PSA-targeted Alpha-, Beta- and Positron Emitting Immuno-Theranostics in Murine Prostate Cancer Models and Non-Human Primates 153 126 14 10

High levels of frataxin overexpression leads to mitochondrial and cardiac toxicity in mouse models 153 95 10

Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids 153 126 64 14 10 3

Targeted delivery of acid alpha-glucosidase corrects skeletal muscle phenotypes in Pompe disease mice 153 10 3

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis 153 10 1

Highly Sensitive Identification of Lymphatic and Hematogenous Metastasis Routes of Novel Radiolabeled Exosomes Using Non-invasive PET Imaging 153 10

Cell-specific and targeted delivery of RNA moieties 153 10 3

Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment 153 10

Host immune responses after suprachoroidal delivery of AAV8 in nonhuman primate eyes 153 10

ImmunoPET as Stoichiometric Sensor for Glypican-3 in Models of Hepatocellular Carcinoma 153 14 10

Methamphetamine enhances caveolar transport of therapeutic drugs across the rodent blood-brain barrier 153 10

Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands 153 10

Controlling wireframe DNA origami nuclease degradation with minor groove binders 153 85

The Safety of a Therapeutic Product Composed of a Combination of Stem Cell Released Molecules from Adipose Mesenchymal Stem Cells and Fibroblasts 153 57 10

Modulating the Blood-Brain Barrier by Light Stimulation of Molecular-Targeted Nanoparticles 153

A Safe Harbor-Targeted CRISPR/Cas9 Homology Independent Targeted Integration (HITI) System for Multi-Modality Reporter Gene-Based Cell Tracking 153 33 18

Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity 126 14 10 3

Post-capillary venules is the locus for transcytosis of therapeutic nanoparticles to the brain. 153 18

Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of Erythropoietic Protoporphyria 153 10 3

Ultra-Low Colcemid Doses Induce Microtubule Dysfunction as Revealed by Super-Resolution Microscopy 153 126 10

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses 88 27 10 3

New models to study plasma cells in mouse based on the restriction of IgJ expression to antibody secreting cells. 153 10

A novel and potent thrombolytic fusion protein consisting of anti-insoluble fibrin antibody and mutated urokinase 153 64 10

Radiosynthesis and Preclinical Evaluation of Ga-NOTA-Folate for PET Imaging of Folate Receptor βPositive Macrophages 153 10

Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides 153 88 45 10

Rapid and cost-effective development of stable clones for the production of anti-Ebola monoclonal antibodies in HEK293T cells 153 24 18 10

Nanoparticle-mediated microRNA-145 Delivery for Vascular Smooth Muscle Cell Phenotype Modulation and Atherosclerosis Treatment 153 85 10 3

BTP-7, a novel peptide for therapeutic targeting of malignant brain tumors 126 14 10 3

Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T cell Mediated Anti-Tumor Response and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression 126 14 10 3

MiR-101a loaded Extracellular Nanovesicles as Bioactive Carriers for Cardiac Repair 153 85 10

Chemokine receptor 2-targeted molecular imaging in pulmonary fibrosis 10 3

Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome 153 10

Cabozantinib unlocks efficient in vivo targeted delivery of neutrophil-loaded nanoparticles into murine prostate tumors 126 14 10 3

Efficient Development of Platform Cell Lines Using CRISPR-Cas9 and Transcriptomics Analysis 33 9

Prior vaccination with the rVSV-ZEBOV vaccine does not interfere with but improves the efficacy of postexposure antibody treatment in nonhuman primates exposed to Ebola virus 153 24 10

PD-1 Specific 'Blocking' Antibodies That Deplete PD-1+ T Cells Present An Inconvenient Variable In Pre-clinical Immunotherapy Experiments 88 14 10

The central THαβ immunity associated cytokine: IL-10 has a strong anti-tumor ability toward established cancer models in vivo and toward cancer cells in vitro 188 27 10 3

A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival probability of tuberculous meningitis patients treated with adjunctive dexamethasone 153 10

Inflammation mediates lung cancer-induced increase in the epidermal green autofluorescence of mice 153 10

Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia 10 3

μ-Lat: A Mouse Model to Evaluate Human Immunodeficiency Virus Eradication Strategies 153 10 3

A Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug Delivery 7 3

Hypoxic gene expression in chronic hepatitis B infected patients is not observed in state-of-art in vitro and mouse infection models 153 10 3

An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy. 188 153 10

Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques 164 10

Longitudinal tracking reveals sustained polyclonal repopulation of human-HSPC in humanized mice despite vector integration bias 153 57

TNFRSF14 (HVEM) is a novel immune checkpoint blockade that can be targeted by a monoclonal antibody to improve anti-tumor immunity in humanized mice 126 14 10 3

Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge 24 10 1

Cyclic pentapeptide cRGDfK enhances the inhibitory effect of sunitinib on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells 98 14 10 3

Allele-specific antisense oligonucleotide therapy for dominantly inherited hearing impairment DFNA9. 153 10

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling 36 1

Vascular Endothelial Growth Factor as an Immediate-Early Activator of UV-induced Skin Injury 10 3

Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma 126 14 10 3

Restructuring of the Immune Contexture Improves Checkpoint Blockade Efficacy in Murine Lung Cancer 126 14 10

ALPPL2 is a highly specific and targetable tumor cell surface antigen 14 10 9 3

A homodimeric aptamer variant generated from ligand-guided selection activates T-cell receptor cluster of differentiation three complex 153 129 85

Use of convalescent serum reduces severity of COVID-19 in nonhuman primates 24 1

Paracoccidioides HSP90 can be found in the cell surface and is a target for antibodies with therapeutic potential 114 10

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor 7 3

Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts 126 14 10 9

Circulating levels of epirubicin cause endothelial senescence while compromising metabolic activity and vascular function 10 3

Priming of MSCs with inflammation-relevant signals affects extracellular vesicle biogenesis, surface markers, and modulation of T cell subsets 110 10 3

Pre-existing intratumoral CD8 T cells substantially contribute to control tumors following therapeutic anti-CD40 and polyI:C based vaccination 88 14 10 3

Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs 36 1

Proteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection 153 10 3

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 191 36 24 1

A Strategy to Treat COVID-19 Disease with Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Non-clinical Pharmacokinetic Study 44 1

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection 36 1

Tamoxifen repurposing to combat infections by multidrug-resistant Gram-negative bacilli 52 10

Organ-restricted vascular delivery of nanoparticles for lung cancer therapy 64 14 10

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine 24 1

Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31 164 10

IgY antibodies against Ebola virus possess post-exposure protection and excellent thermostability 24 10

Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening 44 1

The immunocytokine L19-TNF eradicates Sarcomas in combination with Chemotherapy or with immune check-point inhibitors 126 14 10 3

Remodeling gut microbiota by Streptococcus thermophilus 19 attenuates inflammation in septic mice 101 10 3

Development of a humanized mouse model to analyze antibodies specific for human leukocyte antigen (HLA) 88 27 10 3

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery 6

MSCs Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma 126 14 10 3

Tissue-resident memory CD8 T-cell responses elicited by a single injection of a multi-target COVID-19 vaccine 24 1

Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome 126 14 10

Lipopolysaccharide administration alters extracellular vesicles in human lung-cancer cells and mice 10 3

Ceftazidime Is a Potential Drug to Inhibit SARS-CoV-2 Infection In Vitro by Blocking Spike Protein-ACE2 Interaction 36 1

A targeted computational screen of the SWEETLEAD database reveals FDA-approved compounds with anti-dengue viral activity 44 41 10

Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy 64 14 10 3