Topic 181

f508del biochemistry depends conformation cftr nmr located membrane anion atomic cf appears cystic protein ail galnts y876 y898 terminus formation vitronectin src binding conformational gbf1 nuclear proteins unfolding strive pellicle residues sec7 pestis membranes arf1 5lo phosphotungstate trafficking fibrosis nbd1 nbd resonance presence transmembrane domain perturbation departs prevent present equilibrium adopt leukotrienes sedimentation diarrhoeas envelopes yersinia partial arf conformations homotrimeric relocation gef flush correctors r1070w potentiators induces lipoxygenase site melting channel conversion promotes flap fluorescence potentiator subdomain spectroscopy monomeric swapped transitions deadly milieu favoring tubular nanodiscs vx 250 corroborates traffic action revertant containing gtp 770 transepithelial noxious arachidonic helical b2c363org

7 items. Top items listed below.

A Topological Switch Enables Misfolding of the Cystic Fibrosis Transmembrane Conductance Regulator 181 63 8 3

Preferred Conformations in the Intrinsically Disordered Region of Human CPEB3 Explain its Role in Memory Consolidation 181 6

Fluorescence assay for simultaneous quantification of CFTR ion-channel function and plasma membrane proximity 181 64 8

Mechanistic Studies of the Stabilization of Insulin Helical Structure by Coomassie Brilliant Blue 181 6

Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions. 181 8 3

Resolving atomic site interactions of the Y. pestis outer membrane protein Ail with human serum in the bacterial cell envelope 181 8 3

Src activates retrograde membrane traffic through phosphorylation of GBF1 181 34 8 3

The ΔF508 CFTR defect: molecular mechanism of suppressor mutation V510D and the contribution of transmembrane helix unraveling 63 8 3

Conformational states of the cytoprotective protein Bcl-xL 91 78 63 8 3

ARF1 dimerization is essential for vesicle trafficking and dependent on activation by ARF-GEF dimers in Arabidopsis 34 8 3

State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane 163 91 82 8 3

Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes 34 8 3

Human DND1-RRM2 forms a non-canonical domain-swapped dimer 6 3

Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation 78 63 8

Two-step mechanism of J-domain action in driving Hsp70 function 6 3

Molecular dynamics reveals complex compensatory effects of ionic strength on the SARS-CoV-2 Spike/hACE-2 interaction 6 1

Negative controls of chemical probes can be misleading 6

A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy 34 8 3

The utility of native MS for understanding the mechanism of action of repurposed therapeutics in COVID-19: heparin as a disruptor of the SARS-CoV-2 interaction with its host cell receptor. 6 1

A benzene-mapping approach for uncovering cryptic pockets in membrane-bound proteins 6

Tau amyloidogenesis begins with a loss of its conformational polymorphism 6 3

The electrostatic allostery could be the trigger for the changes in dynamics for the PDZ domain of PICK1 63 8 3

Double Domain Swapping in Human γC and γD Crystallin Drives Early Stages of Aggregation 6

Protein dynamics enables phosphorylation of buried residues in Cdk2/Cyclin A-bound p27 149 91 8

Strong reduction of the chain rigidity of hyaluronan by selective binding of Ca2+ ions 6

Comparative analysis of non structural protein 1 of SARS-COV2 with SARS-COV1 and MERS-COV: An in silico study 6 1

Identification of a Nonsense-Mediated Decay pathway at the Endoplasmic Reticulum 6 3

The Structures of SctK and SctD from Pseudomonas aeruginosa Reveal the Interface of the Type III Secretion System Basal Body and Sorting Platform 6

Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein 6

Structure of a proton-powered molecular motor that drives protein transport and gliding motility 51 8 3

Investigation of the effect of temperature on the structure of SARS-Cov-2 Spike Protein by Molecular Dynamics Simulations 6 1

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14 51 8 3

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner 6 3

A sodium-dependent communication pathway across class A G-protein coupled receptors 91 63 8 3

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation 34 8 3

Proposed allosteric inhibitors bind to the ATP site of CK2α 6

C subunit of the ATP synthase is an amyloidogenic channel-forming peptide: possible implications in mitochondrial pathogenesis 78 8 3

Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling 6

A series of Orai1 gating checkpoints in transmembrane and cytosolic regions requires clearance for CRAC channel opening 187 6 3

Structure of human ferroportin bound to hepcidin reveals mechanisms of iron homeostasis 51 8 3

The intrinsically disordered N-terminus of the voltage-dependent anion channel 91 78 8

Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells 126 10

Quantitative study of unsaturated transport of glycerol through aquaglyceroporin that has high affinity for glycerol 6

DNA Binding Induces a cis to trans Switch in Cre Recombinase to Enable Intasome Assembly 63 8

Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact site 8 3

STING Promotes Breast Cancer Cell Survival by an Inflammatory-Independent Nuclear Pathway Enhancing the DNA Damage Response 6 3

LC3B phosphorylation regulates FYCO1 binding anddirectional transport of autophagosomes 6 3

Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses 6 1

High-affinity agonist binding to C5aR results from a cooperative two-site binding mechanism 63 8

Understanding the role of apolipoprotein A-I in atherosclerosis. Post-translational modifications synergize dysfunction? 6

Strategies for identifying dynamic regions in protein complexes: flexibility changes accompany methylation in chemotaxis receptor signaling states 6

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes 8

The Drosophila EGFR ligand mSpitz is delivered to cytoplasmic capes at sites of non-canonical RNA export on the nuclear envelope via the endosomal system 187 6 3

Structural basis of SARS-CoV-2 spike protein induced by ACE2 36 1

Biophysical characterization of the ETV6 PNT domain polymerization interfaces 63 8 3

Binding affinity and conformational preferences influence kinetic stability of short oligonucleotides on carbon nanotubes 6

The conformational distribution of a major facilitator superfamily peptide transporter is modulated by the membrane composition 8

PIP2 promotes conformation-specific dimerization of the EphA2 membrane region 78 8 3

Real-Time Observation of Structure and Dynamics during the Liquid-to-Solid Transition of FUS LC 78 8

The relation between intrinsic protein conformational changes and ligand binding 91 8

Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding 91 8 3

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists 187 6

Cooperativity of membrane-protein and protein-protein interactions control membrane remodeling by epsin 1 and regulate clathrin-mediated endocytosis 78 34 8 3

Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium 6

The 'hidden side' of spin labeled oligonucleotides: Molecular Dynamics study focusing on the EPR-silent components of base pairing 6

Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity 36 24 1

Stability of Human Serum Amyloid A Fibrils 6

Functional and structural characterization of H105Y mutation in MtrR protein of Neisseria gonorrhoeae 52 8

Investigation of the anti-TB potential of selected alkaloid constituents using molecular docking approach 6

Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation 6

Identifying Cancer-Relevant Mutations in the DLC START Domain using Evolutionary and Structure-Function Analyses 142 63 3

Correlated motions of conserved polar motifs lay out a plausible mechanism of G protein-coupled receptor activation. 6 3

Molecular Simulations of Mg2+-induced Folding of the Central Domain of the 16S Ribosomal RNA 6

Multiple binding sites for resin-acid derivatives on the voltage-sensor domain of the Shaker potassium channel 163 82 8 3

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein 51 8

Electric field induced wetting of a hydrophobic gate in a model nanopore based on the 5-HT3 receptor channel 6

Probing acetylated-α-synuclein monomer-aggregate complexes by NMR elucidates mechanism of fibril seeding 78 54 8 3

A joint reaction coordinate for computing the free energy landscape of pore nucleation and pore expansion in lipid membranes 6

Histone tails cooperate to control the breathing of genomic nucleosomes 6

2'-O-methylation alters the RNA secondary structural ensemble 91 8

Decreased calmodulin recruitment triggers PMCA4 dysfunction and pancreatic injury in cystic fibrosis 95 3

SLAP2 adaptor binding disrupts c-CBL autoinhibition to activate ubiquitin ligase function. 102 63 34 8 3

Substrate-dependent accessibility changes in the Na+-dependent C4-dicarboxylate transporter, VcINDY, suggest differential substrate effects in a multistep mechanism. 63 8 3

Structural and dynamic characterization of the C-terminal tail of ErbB2: disordered but not random 149 63 8 3

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution 8

S-acylation is involved in tonoplast targeting of flax resistance protein M 7 3

First 3D-Structural Data of Full-length Rod-Outer-Segment Guanylyl Cyclase 1 in Bovine Retina by Cross-linking/Mass Spectrometry 45 8

Functional and structural characterization of allosteric activation of Phospholipase Cϵ by Rap1A 63 8 3

Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics 6

Intrinsic disorder in the T cell receptor creates cooperativity and controls ZAP70 binding 149 8

Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing 6

CD45 pre-exclusion from the tips of microvilli establishes a phosphatase-free zone for early TCR triggering 6 3

Rapid assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy 44 1

The nervous system is the major target for Gold nanoparticle: Evidence from RNA sequencing data of C. elegans 6

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread 6 3

Structure and reconstitution of a MCU-EMRE mitochondrial Ca2+ uniporter complex 51 8 3

Mg2+-binding shifts the IM30 activity from membrane protection to membrane destabilization 78 8 3

Location specific small RNA annealing to the HCV 5' UTR promotes Hepatitis C Virus replication by favoring IRES formation and stimulating virus translation 6

The Glycosphingolipid GM3 Modulates Conformational Dynamics of the Glucagon Receptor 163 91 78 63 8 3

Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state 51 8 3