For all possible absolute log2 fold changes (LFC), which genes have at least this fold change at a specified False Discovery Rate?
limma_confects(fit, coef = NULL, fdr = 0.05, step = 0.01, trend = FALSE)
A limma MArrayLM object.
Column number of coefficient or contrast to test.
False Discovery Rate to control for.
Granularity of log2 fold changes to test.
nest_confects for details of how to interpret the result.
Results are presented in a table such that for any given LFC, if the reader chooses the genes with abs(confect) less than this they are assured that this set of genes has at least this LFC (with the specified FDR). The confect column may also be viewed as a confidence bound on the LFC of each gene, with a dynamic correction for multiple testing.
fit should be produced using
lmFit, and optionally
contrasts.fit if a contrast is needed. It is not necessary to use
eBayes, this function calls