Create a group effect object to detect differential splicing (or similar). The effect size is the root sum of squared differences of the coefficient from the mean.

group_effect_rssm(design, coef, design_common = NULL)

Arguments

design

Design matrix.

coef

Column number in design matrix of the coefficient to be tested.

design_common

Experimental! Optional sample-level design matrix. For example, this can be used to account for a batch effect or matched samples.

Value

A group effect object.

Details

The coefficient should represent a difference between two conditions.

The idea is to detect differences in differential expression between features in a group (ie exons in a gene).

See also

effect_rssm